Square-wave jerks and smooth pursuit impairment as subtle early signs of brain involvement in Langerhans' cell histiocytosis.
Identifieur interne : 000F01 ( Main/Exploration ); précédent : 000F00; suivant : 000F02Square-wave jerks and smooth pursuit impairment as subtle early signs of brain involvement in Langerhans' cell histiocytosis.
Auteurs : Evangelos Anagnostou [Grèce] ; Sokratis G. Papageorgiou ; Constantinos Potagas ; Theodoros Alexakis ; Nikolaos Kalfakis ; Dimitri AnastasopoulosSource :
- Clinical neurology and neurosurgery [ 0303-8467 ] ; 2008.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen (MeSH), Encéphalopathies (psychologie), Encéphalopathies (étiologie), Gadolinium (MeSH), Histiocytose à cellules de Langerhans (complications), Histiocytose à cellules de Langerhans (psychologie), Humains (MeSH), Imagerie par résonance magnétique (MeSH), Mouvements oculaires (MeSH), Mâle (MeSH), Performance psychomotrice (physiologie), Posture (physiologie), Poursuite oculaire (physiologie), Tomodensitométrie (MeSH), Troubles de la prononciation et de l'articulation (complications), Troubles de la prononciation et de l'articulation (psychologie), Électroencéphalographie (MeSH), Épreuves vestibulaires caloriques (MeSH).
- MESH :
- physiologie : Performance psychomotrice, Posture, Poursuite oculaire.
- psychologie : Encéphalopathies, Histiocytose à cellules de Langerhans, Troubles de la prononciation et de l'articulation.
- étiologie : Encéphalopathies.
- Adulte d'âge moyen, Gadolinium, Histiocytose à cellules de Langerhans, Humains, Imagerie par résonance magnétique, Mouvements oculaires, Mâle, Tomodensitométrie, Troubles de la prononciation et de l'articulation, Électroencéphalographie, Épreuves vestibulaires caloriques.
English descriptors
- KwdEn :
- Articulation Disorders (complications), Articulation Disorders (psychology), Brain Diseases (etiology), Brain Diseases (psychology), Caloric Tests (MeSH), Electroencephalography (MeSH), Eye Movements (MeSH), Gadolinium (MeSH), Histiocytosis, Langerhans-Cell (complications), Histiocytosis, Langerhans-Cell (psychology), Humans (MeSH), Magnetic Resonance Imaging (MeSH), Male (MeSH), Middle Aged (MeSH), Posture (physiology), Psychomotor Performance (physiology), Pursuit, Smooth (physiology), Tomography, X-Ray Computed (MeSH).
- MESH :
- chemical : Gadolinium.
- complications : Articulation Disorders, Histiocytosis, Langerhans-Cell.
- etiology : Brain Diseases.
- physiology : Posture, Psychomotor Performance, Pursuit, Smooth.
- psychology : Articulation Disorders, Brain Diseases, Histiocytosis, Langerhans-Cell.
- Caloric Tests, Electroencephalography, Eye Movements, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Tomography, X-Ray Computed.
Abstract
Central nervous system (CNS) involvement in Langerhans' cell histiocytosis (LCH) has been described as a progressive neurological disorder marked by motor and cognitive decline. Detailed analysis of ocular motor abnormalities is lacking. We report on a 60-year-old male with histologically confirmed LCH who developed oscillopsia and gait ataxia over a 1-year period. Eye movements recorded with infrared oculography revealed a high rate of square-wave jerks (SWJ) with frequencies of 41 min(-1) on average and amplitudes between 1 degrees and 7 degrees , as well as marked impairment of smooth tracking of sinusoidally moving targets. Furthermore, static posturography disclosed increased body sway, with an abnormally high sway path. The initial brain MRI was unremarkable. Due to the presumed cerebellar dysfunction we performed a second MRI 1 year later that disclosed deep cerebellar lesions compatible with LCH relapse within the CNS. The abnormal high SWJ rate and the impaired smooth pursuit performance correctly heralded later involvement of the cerebellum anticipating lesion appearance in the MRI.
DOI: 10.1016/j.clineuro.2007.10.008
PubMed: 18078708
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Papageorgiou</name></author><author><name sortKey="Potagas, Constantinos" sort="Potagas, Constantinos" uniqKey="Potagas C" first="Constantinos" last="Potagas">Constantinos Potagas</name></author><author><name sortKey="Alexakis, Theodoros" sort="Alexakis, Theodoros" uniqKey="Alexakis T" first="Theodoros" last="Alexakis">Theodoros Alexakis</name></author><author><name sortKey="Kalfakis, Nikolaos" sort="Kalfakis, Nikolaos" uniqKey="Kalfakis N" first="Nikolaos" last="Kalfakis">Nikolaos Kalfakis</name></author><author><name sortKey="Anastasopoulos, Dimitri" sort="Anastasopoulos, Dimitri" uniqKey="Anastasopoulos D" first="Dimitri" last="Anastasopoulos">Dimitri Anastasopoulos</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="RBID">pubmed:18078708</idno><idno type="pmid">18078708</idno><idno type="doi">10.1016/j.clineuro.2007.10.008</idno><idno type="wicri:Area/Main/Corpus">000F36</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000F36</idno><idno type="wicri:Area/Main/Curation">000F36</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000F36</idno><idno type="wicri:Area/Main/Exploration">000F36</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Square-wave jerks and smooth pursuit impairment as subtle early signs of brain involvement in Langerhans' cell histiocytosis.</title><author><name sortKey="Anagnostou, Evangelos" sort="Anagnostou, Evangelos" uniqKey="Anagnostou E" first="Evangelos" last="Anagnostou">Evangelos Anagnostou</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Eginition Hospital, University of Athens, Greece. anevan@vivodinet.gr</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Neurology, Eginition Hospital, University of Athens</wicri:regionArea><wicri:noRegion>University of Athens</wicri:noRegion></affiliation></author><author><name sortKey="Papageorgiou, Sokratis G" sort="Papageorgiou, Sokratis G" uniqKey="Papageorgiou S" first="Sokratis G" last="Papageorgiou">Sokratis G. Papageorgiou</name></author><author><name sortKey="Potagas, Constantinos" sort="Potagas, Constantinos" uniqKey="Potagas C" first="Constantinos" last="Potagas">Constantinos Potagas</name></author><author><name sortKey="Alexakis, Theodoros" sort="Alexakis, Theodoros" uniqKey="Alexakis T" first="Theodoros" last="Alexakis">Theodoros Alexakis</name></author><author><name sortKey="Kalfakis, Nikolaos" sort="Kalfakis, Nikolaos" uniqKey="Kalfakis N" first="Nikolaos" last="Kalfakis">Nikolaos Kalfakis</name></author><author><name sortKey="Anastasopoulos, Dimitri" sort="Anastasopoulos, Dimitri" uniqKey="Anastasopoulos D" first="Dimitri" last="Anastasopoulos">Dimitri Anastasopoulos</name></author></analytic><series><title level="j">Clinical neurology and neurosurgery</title><idno type="ISSN">0303-8467</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Articulation Disorders (complications)</term><term>Articulation Disorders (psychology)</term><term>Brain Diseases (etiology)</term><term>Brain Diseases (psychology)</term><term>Caloric Tests (MeSH)</term><term>Electroencephalography (MeSH)</term><term>Eye Movements (MeSH)</term><term>Gadolinium (MeSH)</term><term>Histiocytosis, Langerhans-Cell (complications)</term><term>Histiocytosis, Langerhans-Cell (psychology)</term><term>Humans (MeSH)</term><term>Magnetic Resonance Imaging (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Posture (physiology)</term><term>Psychomotor Performance (physiology)</term><term>Pursuit, Smooth (physiology)</term><term>Tomography, X-Ray Computed (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term><term>Encéphalopathies (psychologie)</term><term>Encéphalopathies (étiologie)</term><term>Gadolinium (MeSH)</term><term>Histiocytose à cellules de Langerhans (complications)</term><term>Histiocytose à cellules de Langerhans (psychologie)</term><term>Humains (MeSH)</term><term>Imagerie par résonance magnétique (MeSH)</term><term>Mouvements oculaires (MeSH)</term><term>Mâle (MeSH)</term><term>Performance psychomotrice (physiologie)</term><term>Posture (physiologie)</term><term>Poursuite oculaire (physiologie)</term><term>Tomodensitométrie (MeSH)</term><term>Troubles de la prononciation et de l'articulation (complications)</term><term>Troubles de la prononciation et de l'articulation (psychologie)</term><term>Électroencéphalographie (MeSH)</term><term>Épreuves vestibulaires caloriques (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Gadolinium</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Articulation Disorders</term><term>Histiocytosis, Langerhans-Cell</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Brain Diseases</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Performance psychomotrice</term><term>Posture</term><term>Poursuite oculaire</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Posture</term><term>Psychomotor Performance</term><term>Pursuit, Smooth</term></keywords><keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Encéphalopathies</term><term>Histiocytose à cellules de Langerhans</term><term>Troubles de la prononciation et de l'articulation</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Articulation Disorders</term><term>Brain Diseases</term><term>Histiocytosis, Langerhans-Cell</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Encéphalopathies</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Caloric Tests</term><term>Electroencephalography</term><term>Eye Movements</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Tomography, X-Ray Computed</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Gadolinium</term><term>Histiocytose à cellules de Langerhans</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Mouvements oculaires</term><term>Mâle</term><term>Tomodensitométrie</term><term>Troubles de la prononciation et de l'articulation</term><term>Électroencéphalographie</term><term>Épreuves vestibulaires caloriques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Central nervous system (CNS) involvement in Langerhans' cell histiocytosis (LCH) has been described as a progressive neurological disorder marked by motor and cognitive decline. Detailed analysis of ocular motor abnormalities is lacking. We report on a 60-year-old male with histologically confirmed LCH who developed oscillopsia and gait ataxia over a 1-year period. Eye movements recorded with infrared oculography revealed a high rate of square-wave jerks (SWJ) with frequencies of 41 min(-1) on average and amplitudes between 1 degrees and 7 degrees , as well as marked impairment of smooth tracking of sinusoidally moving targets. Furthermore, static posturography disclosed increased body sway, with an abnormally high sway path. The initial brain MRI was unremarkable. Due to the presumed cerebellar dysfunction we performed a second MRI 1 year later that disclosed deep cerebellar lesions compatible with LCH relapse within the CNS. The abnormal high SWJ rate and the impaired smooth pursuit performance correctly heralded later involvement of the cerebellum anticipating lesion appearance in the MRI.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18078708</PMID><DateCompleted><Year>2008</Year><Month>06</Month><Day>23</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0303-8467</ISSN><JournalIssue CitedMedium="Print"><Volume>110</Volume><Issue>3</Issue><PubDate><Year>2008</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Clinical neurology and neurosurgery</Title><ISOAbbreviation>Clin Neurol Neurosurg</ISOAbbreviation></Journal><ArticleTitle>Square-wave jerks and smooth pursuit impairment as subtle early signs of brain involvement in Langerhans' cell histiocytosis.</ArticleTitle><Pagination><MedlinePgn>286-90</MedlinePgn></Pagination><Abstract><AbstractText>Central nervous system (CNS) involvement in Langerhans' cell histiocytosis (LCH) has been described as a progressive neurological disorder marked by motor and cognitive decline. Detailed analysis of ocular motor abnormalities is lacking. We report on a 60-year-old male with histologically confirmed LCH who developed oscillopsia and gait ataxia over a 1-year period. Eye movements recorded with infrared oculography revealed a high rate of square-wave jerks (SWJ) with frequencies of 41 min(-1) on average and amplitudes between 1 degrees and 7 degrees , as well as marked impairment of smooth tracking of sinusoidally moving targets. Furthermore, static posturography disclosed increased body sway, with an abnormally high sway path. The initial brain MRI was unremarkable. Due to the presumed cerebellar dysfunction we performed a second MRI 1 year later that disclosed deep cerebellar lesions compatible with LCH relapse within the CNS. The abnormal high SWJ rate and the impaired smooth pursuit performance correctly heralded later involvement of the cerebellum anticipating lesion appearance in the MRI.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Anagnostou</LastName><ForeName>Evangelos</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Neurology, Eginition Hospital, University of Athens, Greece. anevan@vivodinet.gr</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Papageorgiou</LastName><ForeName>Sokratis G</ForeName><Initials>SG</Initials></Author><Author ValidYN="Y"><LastName>Potagas</LastName><ForeName>Constantinos</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Alexakis</LastName><ForeName>Theodoros</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Kalfakis</LastName><ForeName>Nikolaos</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Anastasopoulos</LastName><ForeName>Dimitri</ForeName><Initials>D</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2007</Year><Month>12</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Clin Neurol Neurosurg</MedlineTA><NlmUniqueID>7502039</NlmUniqueID><ISSNLinking>0303-8467</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>AU0V1LM3JT</RegistryNumber><NameOfSubstance UI="D005682">Gadolinium</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D001184" MajorTopicYN="N">Articulation Disorders</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001927" MajorTopicYN="N">Brain Diseases</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName><QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002150" MajorTopicYN="N">Caloric Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004569" MajorTopicYN="Y">Electroencephalography</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005133" MajorTopicYN="N">Eye Movements</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005682" MajorTopicYN="N">Gadolinium</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006646" MajorTopicYN="N">Histiocytosis, Langerhans-Cell</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008279" MajorTopicYN="N">Magnetic Resonance Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011187" MajorTopicYN="N">Posture</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011597" MajorTopicYN="N">Psychomotor Performance</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011698" MajorTopicYN="N">Pursuit, Smooth</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014057" MajorTopicYN="N">Tomography, X-Ray Computed</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2007</Year><Month>08</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2007</Year><Month>10</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2007</Year><Month>10</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>12</Month><Day>15</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2008</Year><Month>6</Month><Day>24</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>12</Month><Day>15</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">18078708</ArticleId><ArticleId IdType="pii">S0303-8467(07)00312-5</ArticleId><ArticleId IdType="doi">10.1016/j.clineuro.2007.10.008</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Grèce</li></country></list><tree><noCountry><name sortKey="Alexakis, Theodoros" sort="Alexakis, Theodoros" uniqKey="Alexakis T" first="Theodoros" last="Alexakis">Theodoros Alexakis</name><name sortKey="Anastasopoulos, Dimitri" sort="Anastasopoulos, Dimitri" uniqKey="Anastasopoulos D" first="Dimitri" last="Anastasopoulos">Dimitri Anastasopoulos</name><name sortKey="Kalfakis, Nikolaos" sort="Kalfakis, Nikolaos" uniqKey="Kalfakis N" first="Nikolaos" last="Kalfakis">Nikolaos Kalfakis</name><name sortKey="Papageorgiou, Sokratis G" sort="Papageorgiou, Sokratis G" uniqKey="Papageorgiou S" first="Sokratis G" last="Papageorgiou">Sokratis G. Papageorgiou</name><name sortKey="Potagas, Constantinos" sort="Potagas, Constantinos" uniqKey="Potagas C" first="Constantinos" last="Potagas">Constantinos Potagas</name></noCountry><country name="Grèce"><noRegion><name sortKey="Anagnostou, Evangelos" sort="Anagnostou, Evangelos" uniqKey="Anagnostou E" first="Evangelos" last="Anagnostou">Evangelos Anagnostou</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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